Saturday, 19 December 2015

What is sonic hedgehog (SHH)?

Q.All are true regarding molecular signaling in neurulation except
a. Hensen's node secretes molecules that lead to neural induction.
b. Noggin, follistatin, and chordin are neural inducers
c. BMP-4 promote  formation of neural ectoderm
d. the notochord  secretes the signaling molecule sonic hedgehog (SHH)
e. Floor plate produces SHH and the winged helix transcription factor hepatocyte nuclear factor (HNF)-3β
ANS.---c

The ventral mesoderm and the early ectoderm itself produce BMPs, especially BMP-4, which inhibit formation of neural ectoderm and promote differentiation of epidermal ectoderm.

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