Sunday, 8 November 2015

PANDA IN BRAIN

514.All are true regarding neuroimaging of Wilson disease except
a. “face of the giant panda” sign in medulla
b. the “bright claustral” sign
c. Diffusion-weighted MR shows variable findings,
d. significant decrease in the NAA/Cr ratio in the parietal-occipital cortex, frontal white matter, and basal ganglia
e. may improve and/or resolve after effective treatment
514.---a


Two specific MRI signs have been described in WD. The better known is the “face of the giant panda” sign , which describes hyperintense signal on long-TR sequences throughout the midbrain with sparing of the red nucleus, the lateral portion of the pars reticulata of the substantia nigra, and a portion of the superior colliculus.


The other sign, the “bright claustral” sign, correlates with focal hyperintense signal of the claustrum on long-TR sequences . In a recent investigation, the “face of the giant panda” sign was found in 12% and the “bright claustral” sign in 4% of patients with WD.

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