552.All are true regarding septooptic dysplasia (SOD) except
a. overrexpression of
dorsalizing gradient genes
b. optic nerve
hypoplasia and deficiency of the septum pellucidum
c. HESX1 gene implicated
d. concurrent
schizencephaly in 50% of patients
e. hypoplasia of the
hypothalamus
ANS ---a
Neural Tube Dorsalizing
Gradient Mutations are divided into those that involve overexpression of
dorsalizing gradient genes, such as duplication of the dorsal horns of the
spinal cord, duplication of dorsal brainstem structures, and the dorsal
interhemispheric variant of HPE, and those that involve underexpression of
dorsalizing gradient genes, such as septooptic dysplasia (SOD).
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