Q1 .Radiopharmaceuticals used for BETA amyloid imaging are all except
a, 18F-florbetapir
b.18Fflorbetaben
c. 18F-flutemetamol
d.123I-Ioflupane
1.Ans--d
Q2.All are true regarding beta amyloid imaging except
a.uptake by white matter normal
b.inceased cortical uptake abnormal
c.cerebellum used as internal control
d.crebellum shows most heavy amyloid depostion
2Ans---d
A relatively new group of contrast agents exists that allows visualization of abnormal amyloid deposition . Although the original agent was carbon 11–Pittsburgh compound B, the current major radiopharmaceuticals in this group are all tagged with 18F and include 18F-florbetapir, 18Fflorbetaben, and 18F-flutemetamol. T
At neurologic imaging, normal white matter takes up these agents. The mechanism is not well understood, but research suggests it may bind to myelin-binding proteins and could be used in the workup of demyelinating diseases
At β-amyloid imaging, areas of increased cortical uptake are considered abnormal and correspond to cortical deposition of β-amyloid plaques. An internal control is used to establish a normal uptake pattern, with the cerebellum typically used to compare gray-white differentiation, as the cerebellum rarely has abnormal amyloid accumulation.
RADIOGRAPHICS
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