Q.All are true
regarding Pelizaeus-Merzbacher disease except
a.due to lack of
lipophilin
b.patchy
demyelination with sparing of perivascular white matter
c.preserved internal
capsule and subcortical U fibres
d.diffuse low
signal on T2w
e.hypointense basal
ganglia and thalamus on T2W
ANS.---d
Severe cases of Pelizaeus-Merzbacher
disease show near –total
lack of normal
myelination with diffuse high signal on
T2W image
that extends peripherally to involve the arcuate fibres .
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