DEVELOPMENT OF NEPHRON /KIDNEY

DEVELOPMENT OF NEPHRON  /KIDNEY

• The genitourinary system develop from intemediate mesoderm.
• The human embryos develop three sets of excretory organs or kidney system  during intrauterine life--1.the pronephros 2.the mesonephros and 3.the metanephros.
• The pronephros  is seen in the 3rd week of development and completely degenerates by the start of the 5th week.
• The mesonephros  regresses by the 4th month,howerever it serves as an excretory organ for the embryo while the definitive kidney begins its development.
• The definitive kidney ,metanephros begins as diverticulum(metenephric diverticulum/ureteric bud) from the mesonephros in the sacral region of  embryo.
• The metanephric diverticulum/ureteric bud comes in contact with and penetrates the metanephric mesoderm at approximately the 28th day.
• THE GOMERULUS,PROXIMAL TUBULE ,LOOP OF HENLE AND DISTAL TUBULE  DEVELOPS FROM THE METANEPHRIC MESODERM .
• THE COLLECTING  SYSTEM CONSISTING OF COLLECTING DUCTS ,CALICES ,PELVIS AND URETER DEVELOPS FROM THE METANEPHRIC DIVERTICULUM /URETERIC BUD

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