Wednesday, 12 March 2014

Localization of prostate cancer lesions


18F FACBC PET/CT and T2-weighted MR imaging --- localization of prostate cancer lesions


In an artclie , Baris Turkbey, MD et al ,( 
Radiology ,March 2014 Volume 270, Issue 3)
tried to characterize uptake of 1-amino-3-fluorine 18-fluorocyclobutane-1-carboxylic acid (18F FACBC) in patients with localized prostate cancer, benign prostatic hyperplasia (BPH), and normal prostate tissue and also tried to evaluate its potential utility in delineation of intraprostatic cancers in histopathologically confirmed localized prostate cancer in comparison with magnetic resonance (MR) imaging.
They found that 18F FACBC PET/CT shows higher uptake in intraprostatic tumor foci than in normal prostate tissue., 18F FACBC uptake in tumors is similar to that in BPH nodules. Thus, it is not specific for prostate cancer. Nevertheless, combined 18F FACBC PET/CT and T2-weighted MR imaging enable more accurate localization of prostate cancer lesions than either modality alone.---


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