Mcq — NAFLD

Q.All are true regarding  Nonalcoholic fatty liver disease (NAFLD) except 

1.the leading cause of chronic liver disease in the world 

2.The global prevalence of NAFLD about 25 percent

3.poorly associated  with obesity 

4. an increased mortality rate  mainly due to cardiovascular disease 

Ans —-3

NAFLD is closely associated with obesity and it is liver manifestation of metabolic syndrome 

Q .All are true regarding NAFLD except

1.USG is first line of investigation 

2.Liver biopsy is the gold standard of diagnosis 

3.USG is accurate in diagnosing mild fatty liver

4.MRS is used as reference standard 

Ans—-3

Ultrasonography (US) for assessment of hepatic steatosis is commonly qualitative in nature.US is reliable and accurate in de- tecting moderate-to-severe fatty liver with sensitivity of 84.8% and specificity of 93.6% 

US has several limitations—highly operator-dependent , has poor accuracy in diagnosing mild steatosis and may be less accurate to diagnose steatosis in patients with under- lying hepatic fibrosis.

A recent study revealed that the sensitivity of US was only 65.1% when compared with mag- netic resonance imaging proton density fat fraction (MRI- PDFF) in diagnosing mild steatosis .

To improve the ac- curacy, computer-assisted quantitative US techniques have been developed for the assessment of hepatic steatosis .The most widely reported technique is the computerized hepatorenal index .

However, a more recent study suggested that the hepatorenal ratio was not as good, while acoustic structure quantification (ASQ) from ultrasound echo amplitude was better for the assessment of hepatic steatosis.

Overall, US remains the first-line imaging used to diagnose NAFLD as it is noninvasive, widely available, and relatively inexpenve