Q. Brain tumor may harbor mutations in the genes for the isocitrate dehydrogenases (IDH) and produce 2 - hydroxyglutarate which may be identified by imaging and help in characterization of tumor . Identify the tumor 1.Infiltrating gloms 2.infiltrating meningioma 3.infiltrating medulloblastoma 4.infiltrating teratoma 5.infiltrating ependymoma Ans ——- 1 .
For the WHO 2016 revision, IDH mutation has become definitional for infiltrating gliomas in adults, with 1p/19q codeletion further characterizing the type .Oligodendroglioma is an infiltrating glioma that carries both IDH mutation and 1p/19q codeletion (which does not occur in the absence of IDH mutation). Astrocytoma is an infiltrating glioma that is subdivided in the classification by the presence of IDH mutation and never contains 1p/19q codeletion. REF —- Radiographics
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