-------Perfusion magnetic resonance
(MR) imaging techniques are
widely used in the clinical work-up
of brain tumors because of their ability
to help quantify tumor microvessel proliferation
and permeability and thus to
measure changes associated with neoangiogenesis,
which correlate with tumor
malignancy.
-----Dynamic susceptibility contrast (DSC) MR imaging has been extensively explored for glioma grading , for prognostic assessment , and for differentiating between recurrent tumor and posttreatment changes .
-----Dynamic contrast material–enhanced (DCE) MR imaging has been recently introduced in the preoperative assessment and follow-up of brain tumors.
------The DCE signal intensity– time curve reflects a combination of tissue perfusion, microvessel permeability, and extravascular-extracellular space , thus allowing for a multiparametric characterization of tumor microvasculature.
------The advantages of DCE over DSC are fewer susceptibility artifacts and the quantification of blood-brain barrier (BBB) integrity; indeed, the main interest for DCEderived metrics was initially focused on the volume transfer constant (Ktrans), a permeability marker correlating with BBB disruption and malignancy .
----The advantage of DSC over DCE is better temporal resolution, allowing better estimation of blood volume.
-----Dynamic susceptibility contrast (DSC) MR imaging has been extensively explored for glioma grading , for prognostic assessment , and for differentiating between recurrent tumor and posttreatment changes .
-----Dynamic contrast material–enhanced (DCE) MR imaging has been recently introduced in the preoperative assessment and follow-up of brain tumors.
------The DCE signal intensity– time curve reflects a combination of tissue perfusion, microvessel permeability, and extravascular-extracellular space , thus allowing for a multiparametric characterization of tumor microvasculature.
------The advantages of DCE over DSC are fewer susceptibility artifacts and the quantification of blood-brain barrier (BBB) integrity; indeed, the main interest for DCEderived metrics was initially focused on the volume transfer constant (Ktrans), a permeability marker correlating with BBB disruption and malignancy .
----The advantage of DSC over DCE is better temporal resolution, allowing better estimation of blood volume.
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